From Wikipedia, the free encyclopedia
| Small nucleolar RNA U6-53/MBII-28 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; stemloc; Daub J |
| Seed alignment: |
Moxon SJ |
| Avg length: |
106.9 nucleotides |
| Avg identity: |
83% |
|
Small nucleolar RNA U6-53 (also known as MBII-28) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U6-53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1][2]. snoRNA MBII-202 was originally cloned from mouse brain tissues[3]. This snoRNA possesses sequence complementarity to U6 spliceosomal RNA and is likely to direct its 2'-O-methylation [4].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
- ^ Huttenhofer A, Kiefmann M, Meier-Ewert S, et al (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMID 11387227.
- ^ Ganot, P; Jady BE, Bortolin ML, Darzacq X, Kiss T (1999). "Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA". Mol Cell Biol 19: 6906–6917. PMID 10490628.
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