From Wikipedia, the free encyclopedia
| Small nucleolar RNA U2-19 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Published;PubMed |
| Seed alignment: |
Moxon SJ |
| Avg length: |
78.9 nucleotides |
| Avg identity: |
87% |
|
Small nucleolar RNA U2-19 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U2-19 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. snoRNA U2-19 directs 2'-O-methylation of U2 spliceosomal RNA G-19. [2].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Tycowski, KT; Aab A, Steitz JA (2004). "Guide RNAs with 5' Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa". Curr Biol 14: 1985–1995. doi:10.1016/j.cub.2004.11.003. PMID 15556860.
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