Small nucleolar RNA TBR7

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Small nucleolar RNA TBR7

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Daub J
Seed alignment:	Moxon SJ
Avg length:	74.8 nucleotides
Avg identity:	80%

Small nucleolar RNA TBR7 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA TBR7 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipiation with anti-fibrillarin antibodies ^[2]. It is predicted to guide the 2'O ribosose methylation of 18s ribosomal RNA (rRNA).

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J. Biol. Chem. 275 (19): 14767–76. PMID 10747997.