Small nucleolar RNA TBR5

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Small nucleolar RNA TBR5

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Moxon SJ, Daub J
Seed alignment:	Moxon SJ
Avg length:	90.0 nucleotides
Avg identity:	80%

TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1,2].

[edit] References

[1] Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
[2] Dunbar, DA; Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J Biol Chem 275: 14767–14776. doi:10.1074/jbc.M001180200. PMID 10747997.