Small nucleolar RNA SNORD87

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Small nucleolar RNA SNORD87

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; RNAFOLD;
Seed alignment:	Moxon SJ
Avg length:	81.9 nucleotides
Avg identity:	93%

SNORD87 (also known as U87) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U87 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]. ^[2]

U87 was identified by purification from yeast (Saccharomyces cerevisiae) ^[3] and is the orthologue of mouse MBII-276 ^[4]

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
^ Gogolevskaya IK, Makarova JA, Gause LN, Kulichkova VA, Konstantinova IM, Kramerov DA (2002). "U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells". Gene 292 (1-2): 199–204. PMID 12119114.
^ Huttenhofer, A; Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20: 2943–2953. doi:10.1093/emboj/20.11.2943. PMID 11387227.