Small nucleolar RNA SNORD73

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Small nucleolar RNA SNORD73

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Griffiths-Jones SR
Seed alignment:	Griffiths-Jones SR
Avg length:	68.7 nucleotides
Avg identity:	84%

snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the euyaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA) ^[2]. U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA^[3].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-ribose methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Rebane, A; Tamme R, Laan M, Pata I, Metspalu A (1998). "A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes". Gene 210: 255–263. doi:10.1016/S0378-1119(98)00070-5. PMID 9573378.
^ Rebane, A; Roomere H, Metspalu A. (2002). "Locations of several novel 2'-O-methylated nucleotides in human 28S rRNA". BMC Mol Biol. 3: 1. doi:10.1186/1471-2199-3-1. PMID 11897011.