Small nucleolar RNA SNORD57

From Wikipedia, the free encyclopedia

This article or section contains too much jargon and may need simplification or further explanation.
Please discuss this issue on the talk page, and/or remove or explain jargon terms used in the article. Editing help is available.
This article has been tagged since June 2007.

Small nucleolar RNA SNORD57

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Daub J
Seed alignment:	Moxon SJ
Avg length:	69.6 nucleotides
Avg identity:	88%

snoRNA U57 (also known as SNORD57) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U57 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs^[2]. Its is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3.

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85 (7): 1077–88. PMID 8674114.