Small nucleolar RNA SNORD53

From Wikipedia, the free encyclopedia

Small nucleolar RNA SNORD53

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; Moxon SJ
Seed alignment:	Moxon SJ
Avg length:	76.2 nucleotides
Avg identity:	82%

snoRNA U53 (also known as SNORD53) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]^[2].

U53 was originally cloned from HeLa cells and is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) at residue C3848^[3]^[4]. Its is related to mouse snoRNA MBII-35 ^[5].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85 (7): 1077–88. PMID 8674114.
^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, et al (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMID 11387227.