Small nucleolar RNA SNORD32

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Small nucleolar RNA SNORD32

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; Griffiths-Jones SR; Daub J
Seed alignment:	Griffiths-Jones SR
Avg length:	82.0 nucleotides
Avg identity:	90%

snoRNA U32 (also known as SNORD32) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U32 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

U32 is an encoded in intron 2 of the ribosomal protein L13 gene in human and mouse^[2] and is predicted to guide the 2'O-ribose methylation of both 18S ribosomal RNA (rRNA) residue G1328 and 28S rRNA residue A1511^[2]^[3]. U32A share the same host gene with the C/D box snoRNAs U33, U34 and U35A (RPL13A)^[3].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ ^a ^b Nicoloso, M; Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J Mol Biol 260: 178–195. doi:10.1006/jmbi.1996.0391. PMID 8764399.
^ ^a ^b Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.