Small nucleolar RNA SNORD29

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Small nucleolar RNA SNORD29

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD; Moxon SJ, Daub J
Seed alignment:	Moxon SJ; Griffiths-Jones SR
Avg length:	75.1 nucleotides
Avg identity:	70%

SNORD29 (also known as U29) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

U29 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]^[2].

In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene) ^[3]^[4]. U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A4493 ^[5]^[6].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
^ Tycowski KT, Shu MD, Steitz JA (1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature 379 (6564): 464–6. doi:10.1038/379464a0. PMID 8559254.
^ Tycowski KT, Smith CM, Shu MD, Steitz JA (1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14480–5. PMID 8962077.
^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85 (7): 1077–88. PMID 8674114.
^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.