From Wikipedia, the free encyclopedia
| Small nucleolar RNA SNORD24 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD; Griffiths-Jones SR, Daub J |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
81.6 nucleotides |
| Avg identity: |
72% |
|
U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs [1]. C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets [2,3]. U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu [4]. The U76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene [5]. snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.
[edit] References
- [1] Qu, LH; Henry Y, Nicoloso M, Michot B, Azum MC, Renalier MH, Caizergues-Ferrer M, Bachellerie JP (1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA". Nucleic Acids Res 23: 2669–2676. doi:10.1093/nar/23.14.2669. PMID 7651828.
- [2] Nicoloso, M; Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J Mol Biol 260: 178–195. doi:10.1006/jmbi.1996.0391. PMID 8764399.
- [3] Kiss-Laszlo, Z; Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85: 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.
- [4] Gilley, J; Fried M (1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA Cell Biol 17: 591–602. PMID 9703018.
- [5] Hirose, T; Steitz JA (2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proc Natl Acad Sci U S A 98: 12914–12919. doi:10.1073/pnas.231490998. PMID 11606788.
[edit] External links
