Small nucleolar RNA SNORD20

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Small nucleolar RNA SNORD20

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; Griffiths-Jones SR
Seed alignment:	Griffiths-Jones SR
Avg length:	80.2 nucleotides
Avg identity:	100%

snoRNA U20 (also known as SNORD20) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U20 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat ^[2]. Its is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804 ^[3] ^[4].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Nicoloso, M; Caizergues-Ferrer M, Michot B, Azum MC, Bachellerie JP (1994). "U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals". Mol Cell Biol 14: 5766–5776. PMID 8065311.
^ Kiss-Laszlo, Z; Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85: 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.
^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.