Small nucleolar RNA SNORD17

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Small nucleolar RNA SNORD17

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; RNAalifold
Seed alignment:	Marantidis E.
Avg length:	232.0 nucleotides
Avg identity:	90%

SNORD17 (also known as HBI-43) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBI-43 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

This snoRNA is the human orthologue of mouse HBI-43 ^[2]. HBII-43 is predicted to guide 2'O-ribose methylation of 28s ribosomal RNA (rRNA) at position U3797 ^[3]. This residue (U3797) is also predicted to be pseudouridylated (the uridine residue is converted to pseudouridine) by the H/ACA box snoRNA ACA48 ^[3] .

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Huttenhofer, A; Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20: 2943–2953. doi:10.1093/emboj/20.11.2943. PMID 11387227.
^ ^a ^b Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.