Small nucleolar RNA SNORD16

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Small nucleolar RNA SNORD16

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD
Seed alignment:	Griffiths-Jones SR
Avg length:	98.5 nucleotides
Avg identity:	81%

snoRNA U16 (also known as SNORD16) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U16 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1].

U81 i spredicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A484 ^[2]and is encoded within an intron of the gene for ribosomal proteins L1 in animals ^[3]. This snoRNA was independently named MBII-98 in mouse ^[4].

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85 (7): 1077–88. PMID 8674114.
^ Fragapane P, Prislei S, Michienzi A, Caffarelli E, Bozzoni I (1993). "A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA". EMBO J. 12 (7): 2921–8. PMID 8335006.
^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, et al (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMID 11387227.