Small nucleolar RNA SNORA77

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Small nucleolar RNA SNORA77

Type:	Gene;snRNA;snoRNA;HACA-box;
2° structure:	PMID:16373490
Seed alignment:	Predicted; RNAalifold
Avg length:	124.5 nucleotides
Avg identity:	82%

Small nucleolar RNA SNORA77 (also known as ACA63) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

SNORA77 was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis^[1]. It belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and conserved H/ACA-box motifs ^[2].

SNORA77 is proposed to guide the pseudouridylation of 18S ribosomal RNA (rRNA) residue U814^[3]. Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

[edit] References

^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. doi:10.1261/rna.2210406. PMID 16373490.
^ Kiss AM, Jady BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
^ Lestrade L, Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34 (Database issue): D158–62. doi:10.1093/nar/gkj002. PMID 16381836.