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| Small nucleolar RNA SNORA76 |
 |
| Type: |
Gene;snRNA;snoRNA;HACA-box; |
| 2° structure: |
PMID:16373490 |
| Seed alignment: |
Predicted; RNAalifold |
| Avg length: |
132.1 nucleotides |
| Avg identity: |
70% |
|
In molecular biology, SNORA76 (also known as ACA62) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. [1].
This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis [2]. ACA62 is proposed to guide the pseudouridylation of 18S rRNA U34 and U105 [2] [3].
[edit] References
- ^ Kiss, AM; Jady BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol Cell Biol 24: 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
- ^ a b Schattner P, Barberan-Soler S, Lowe TM; (2006). "A computational screen for mammalian pseudouridylation guide H/ACARNAs.". RNA 12: 15–25. doi:10.1261/rna.2210406. PMID 16373490.
- ^ Lestrade L, Weber MJ; (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs.". Nucleic Acids Res 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
[edit] External links
