Small nucleolar RNA SNORA75

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Small nucleolar RNA SNORA75

Type:	Gene; snRNA; guide; HACA-box;
2° structure:	Predicted; PFOLD; Griffiths-Jones SR
Seed alignment:	Griffiths-Jones SR
Avg length:	130.4 nucleotides
Avg identity:	73%

U23 belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs [3]. Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA (SL RNA) as possibly other, still unknown cellular RNAs [3]. U23 can direct the pseudouridylation of U97 in human 18S rRNA. U23 is encoded within intron 12 of the nucleolin gene in human, mouse, rat chicken, and Xenopus laevis.

[edit] References

[1] Ganot, P; Caizergues-Ferrer M, Kiss T (1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes Dev 11: 941–956. doi:10.1101/gad.11.7.941. PMID 9106664.
[2] Bachellerie, JP; Cavaille J, Huttenhofer A (2002). "The expanding snoRNA world". Biochimie 84: 775–790. doi:10.1016/S0300-9084(02)01402-5. PMID 12457565.
[3] Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.