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| Small nucleolar RNA SNORA74 |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Predicted; PFOLD; Griffiths-Jones SR |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
197.8 nucleotides |
| Avg identity: |
76% |
|
Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.[2][3]
[edit] References
- ^ Ganot, P; Caizergues-Ferrer M, Kiss T (1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes Dev 11: 941–956. doi:10.1101/gad.11.7.941. PMID 9106664.
- ^ Kiss, T; Bortolin ML, Filipowicz W (1996). "Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin". Mol Cell Biol 16: 1391–1400. PMID 8657112.
- ^ Bortolin, ML; Kiss T (1998). "Human U19 intron-encoded snoRNA is processed from a long primary transcript that possesses little potential for protein coding". RNA 4: 445–454. PMID 9630250.
[edit] External links
