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| Small nucleolar RNA SNORA73 |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR; Cervelli et al, PubMed |
| Avg length: |
207.7 nucleotides |
| Avg identity: |
71% |
|
In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS).[1] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms.[2]
[edit] References
- ^ Enright, CA; Maxwell ES, Eliceiri GL, Sollner-Webb B (1996). "5'ETS rRNA processing facilitated by four small RNAs: U14, E3, U17, and U3". RNA 2: 1094–1099. PMID 8903340.
- ^ Cervelli, M; Cecconi F, Giorgi M, Annesi F, Oliverio M, Mariottini P (2002). "Comparative Structure Analysis of Vertebrate U17 Small Nucleolar RNA (snoRNA)". J Mol Evol 54: 166–179. doi:10.1007/s00239-001-0065-2. PMID 11821910.
[edit] External links
