Small nucleolar RNA SNORA64/SNORA10 family

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Small nucleolar RNA SNORA64/SNORA10 family

Type:	Gene; snRNA; guide; HACA-box;
2° structure:	Published; PubMed
Seed alignment:	PubMed, Daub J
Avg length:	132.4 nucleotides
Avg identity:	70%

Small nucleolar RNA SNORA10 is homologous to SNORA64 and belongs to the H/ACA class of small nucleolar RNAs (snoRNAs), a family of ncRNAs involved in the maturation of ribosomal RNA ^[1]. This family act as guides in the modification of uridines to pseudouridines ^[2]. This family includes the human snoRNAs U64 and ACA10 and mouse MBI-29, guiding the pseudouridylation of residue U4491 of 28S rRNA, residue U210 of 18S rRNA and 28S rRNA U4331 ^[3]^[4]^[5].

[edit] References

^ Narayanan A, Lukowiak A, Jády BE, et al (1999). "Nucleolar localization signals of box H/ACA small nucleolar RNAs". EMBO J. 18 (18): 5120–30. doi:10.1093/emboj/18.18.5120. PMID 10487763.
^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
^ Ofengand J, Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J. Mol. Biol. 266 (2): 246–68. doi:10.1006/jmbi.1996.0737. PMID 9047361.
^ Kiss AM, Jády BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. doi:10.1261/rna.2210406. PMID 16373490.