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| Small nucleolar RNA SNORA40 |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Predicted; RNAalifold |
| Seed alignment: |
Marantidis E |
| Avg length: |
126.2 nucleotides |
| Avg identity: |
80% |
|
The small nucleolar RNA ACA40 belongs to the H/ACA family of snoRNAs and guides the pseudouridylation of 28S rRNA subunit at position U4565. snoRNA ACA40 was originally discovered using large-scale cloning by Kiss et al. (2004)[1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues 28S rRNA U4546 and 18S rRNA 1174 [1] [2]. The pseudouridylation of these residues was previously reported by Ofengand and Bakin (1997) [3] and Maden (1990) [4]. ACA1, ACA8, ACA18, ACA25, ACA32 and ACA40 and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).
[edit] References
- ^ a b Kiss, AM; Jady BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol Cell Biol. 24: 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
- ^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. doi:10.1261/rna.2210406. PMID 16373490.
- ^ Ofengand, J; Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J Mol Biol. 266: 246–268. doi:10.1006/jmbi.1996.0737. PMID 9047361.
- ^ Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Prog. Nucleic Acid Res. Mol. Biol. 39: 241–303. PMID 2247610.
[edit] External links
