From Wikipedia, the free encyclopedia
| Small nucleolar RNA SNORA11 |
 |
| Type: |
Gene;snRNA;snoRNA;HACA-box; |
| 2° structure: |
INFERNAL |
| Seed alignment: |
Predicted; RNAalifold; |
| Avg length: |
128.4 nucleotides |
| Avg identity: |
78% |
|
Small nucleolar RNA SNORA11 (also known as U107) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA). U107 has a predicted hairpin-hinge-hairpin-tail structure and is predicted to be a member of the H/ACA box class of snoRNAs that guide the sites of modification of uridines to pseudouridines [1]. This snoRNA was identified by RT-PCR from blood cells and its expression confirmed by Northern blot analysis [2]. There is no predicted RNA target for this guide snRNA [2].
[edit] References
- [1] Kiss AM, Jady BE, Bertrand E, Kiss T; (2004). "Human box H/ACA pseudouridylation guide RNA machinery.". Mol Cell Biol 24: 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
- [2] Gu AD, Zhou H, Yu CH, Qu LH; (2005). "A novel experimental approach for systematic identification of boxH/ACA snoRNAs from eukaryotes.". Nucleic Acids Res 33: e194-. doi:10.1093/nar/gni185. PMID 16361266.
- [3] Lestrade L, Weber MJ; (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs.". Nucleic Acids Res 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
[edit] External links
