From Wikipedia, the free encyclopedia
| Small nucleolar RNA R38 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD, Griffiths-Jones SR |
| Seed alignment: |
INFERNAL |
| Avg length: |
84.4 nucleotides |
| Avg identity: |
58% |
|
Small nucleolar RNA R38 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA R38 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. snoRNA R38 has been identified in human, yeast [2], Arabidopsis thaliana [3] and Oryza sativa [4]. snoRNA R38 guides the methylation of 2'-O-ribose sites in 28S rRNA.
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Bachellerie JP, Michot B, Nicoloso M, Balakin A, Ni J, Fournier MJ (1995). "Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA". Trends Biochem. Sci. 20 (7): 261–4. PMID 7667877.
- ^ Qu LH, Meng Q, Zhou H, et al (2001). "Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana". Nucleic Acids Res. 29 (7): 1623–30. PMID 11266566.
- ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. PMID 12736310.
[edit] External links
