From Wikipedia, the free encyclopedia
| Small nucleolar RNA R32/R81/Z41 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ, Daub J |
| Seed alignment: |
Moxon SJ |
| Avg length: |
95.6 nucleotides |
| Avg identity: |
84% |
|
Small nucleolar RNA Z41 (homologous to R32 and R81) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z41 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1] [2]. Plant snoRNA Z41 was identified in screens of Arabadopsis thaliana [3] [4].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
- ^ Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID 11469857.
- ^ Qu LH, Meng Q, Zhou H, et al (2001). "Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana". Nucleic Acids Res. 29 (7): 1623–30. PMID 11266566.
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