Small nucleolar RNA R24
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Small nucleolar RNA R24 (also known as snoRNA R24) is a non-coding RNA (ncRNA) molecule identified in plants which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
R24 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1][2].
snoR24 was originally identified in Arabidopsis thaliana and is proposed to acts as a methylation guide for 18S ribosomal RNA (rRNA) in plants [3].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:. PMID 12215523.
- ^ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–8. PMID 12007400.
- ^ Marker C, Zemann A, Terhörst T, et al (2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Curr. Biol. 12 (23): 2002–13. PMID 12477388.
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