Small nucleolar RNA Me28S-Am2634

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Small nucleolar RNA Me28S-Am2634

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; ILM; Daub J
Seed alignment:	PubMed
Avg length:	90.2 nucleotides
Avg identity:	83%

Small nucleolar RNA Me28S-Am2634 (also known as snoRNA Me28S-Am2634) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis of other small nuclear RNAs (snRNAs). Small nucleolar RNAs (snoRNAs) are modifiying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

snoRNA Me28S-Am2634 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]. It is predicted to guide the 2'-O-methylation of 28S ribosomal RNA (rRNA) residue A-2634 ^[2].

This snoRNA has currently only been identified in Drosophila melanogaster.

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Huang ZP, Zhou H, He HL, Chen CL, Liang D, Qu LH (2005). "Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs". RNA 11 (8): 1303–16. doi:10.1261/rna.2380905. PMID 15987805.