From Wikipedia, the free encyclopedia
| Small nucleolar RNA Me28S-Am2589 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ, Daub J |
| Seed alignment: |
PubMed |
| Avg length: |
108.0 nucleotides |
| Avg identity: |
74% |
|
Small nucleolar RNA Me28S-Am2589 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Me28S-Am2589 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. It is predicted that this family directs 2'-O-methylation of 28S A-2589 [2].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Huang, ZP; Zhou H, He HL, Chen CL, Liang D, Qu LH (2005). "Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs". RNA. 11: 1303–1316. doi:10.1261/rna.2380905. PMID 15987805.
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