Small nuclear ribonucleoprotein D1

From Wikipedia, the free encyclopedia

Small nuclear ribonucleoprotein D1 polypeptide 16kDa

PDB rendering based on 1b34.

Available structures: 1b34

Identifiers

Symbol(s)

SNRPD1; HsT2456; SMD1; SNRPD

External IDs

OMIM: 601063 MGI: 98344 HomoloGene: 5053

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • spliceosome • cytoplasm • small nuclear ribonucleoprotein complex
Biological Process:	• spliceosome assembly • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006938 (mRNA)
NP_008869 (protein)

NM_009226 (mRNA)
NP_033252 (protein)

Location

Chr 18: 17.45 - 17.46 Mb

Chr 18: 10.62 - 10.63 Mb

Pubmed search

[1]

[2]

Small nuclear ribonucleoprotein D1 polypeptide 16kDa, also known as SNRPD1, is a human gene.

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.^[1]

[edit] References

^ Entrez Gene: SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa.

[edit] Further reading

Lehmeier T, Foulaki K, Lührmann R (1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5.". Nucleic Acids Res. 18 (22): 6475-84. PMID 1701240.
Renz M, Heim C, Bräunling O, et al. (1989). "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases.". Clin. Chem. 35 (9): 1861-3. PMID 2528429.
Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen.". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832-6. PMID 3260384.
Lehmeier T, Raker V, Hermann H, Lührmann R (1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12317-21. PMID 7527560.
Sun D, Ou YC, Hoch SO (1997). "Analysis of genes for human snRNP Sm-D1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm-E and U1 snRNA genes.". Gene 189 (2): 245-54. PMID 9168134.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013-21. PMID 9323129.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63-9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.". Cell 96 (3): 375-87. PMID 10025403.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181-94. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177-86. PMID 10725331.
Mammoto A, Sasaki T, Kim Y, Takai Y (2000). "Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking.". J. Biol. Chem. 275 (18): 13167-70. PMID 10747849.
Brahms H, Raymackers J, Union A, et al. (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies.". J. Biol. Chem. 275 (22): 17122-9. doi:10.1074/jbc.M000300200. PMID 10747894.
Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins.". Hum. Mol. Genet. 9 (13): 1977-86. PMID 10942426.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569-81. doi:10.1093/emboj/19.23.6569. PMID 11101529.
Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins.". Nat. Struct. Biol. 8 (1): 27-31. doi:10.1038/83014. PMID 11135666.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1-2): 187-96. doi:10.1093/emboj/20.1.187. PMID 11226169.
Friesen WJ, Massenet S, Paushkin S, et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.". Mol. Cell 7 (5): 1111-7. PMID 11389857.
Park JW, Voss PG, Grabski S, et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein.". Nucleic Acids Res. 29 (17): 3595-602. PMID 11522829.
Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.". Mol. Cell. Biol. 21 (24): 8289-300. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266.
Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc.M109448200. PMID 11714716.