Small Cajal body specific RNA 6
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Small Cajal body specific RNA 6 (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12[1]
U88 is found associated with both fibrillarin and Gar1p and co-localises with coilin in Cajal bodies [1]. It is an unusual guide RNA in that it its composed of both H/ACA box and a C/D box conserved domains domains. Its is predicted to guide 2'-O-methylation of residue U41 of the U5 snRNA [1].
U88 is also closely related to other human snoRNAs scaRNA U87 and a mouse homologue MBI-46 described in [2]. In the human genome both U88 and U87 scaRNAs share the same host gene [1][3].
[edit] References
- ^ a b c d Darzacq, X; Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21: 2746–2756. doi:. PMID 12032087.
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, et al (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:. PMID 11387227.
- ^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:. PMID 16381836.
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