From Wikipedia, the free encyclopedia
| Small Cajal body specific RNA 1 |
 |
| Type: |
Gene; snRNA; guide; scaRNA; |
| 2° structure: |
Predicted; RNAalifold |
| Seed alignment: |
Marantidis E |
| Avg length: |
165.7 nucleotides |
| Avg identity: |
92% |
|
In molecular biology, Small Cajal body specific RNA 1 (also known as scaRNA1 or ACA35) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.
scaRNA1 is a non-coding RNA, which are functional products of gene but not translated into a protein. Such RNA molecules usually contain important secondary structure or ligand binding motifs and are involved in many important biological processes in the cell. More specifically, scaRNAs are a class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
scaRNA1 belongs to the H/ACA box class of guide RNAs, as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1 protein.[2] It is predicted to guide pseudouridylation of the U2 spliceosomal RNA at residue U89.[2]
[edit] References
- Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
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