Small Cajal body specific RNA 16

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Small Cajal body specific RNA 16

Type:	Gene; snRNA; guide; scaRNA;
2° structure:	Predicted; RNAFOLD; Moxon SJ
Seed alignment:	Moxon SJ
Avg length:	182.8 nucleotides
Avg identity:	80%

Small Cajal body specific RNA 16 (also known as SCARNA16 or ACA47) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.^[1]

ACA47 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1 ^[2]. ACA47 is predicted to guide the pseudouridylation of residue U5 of the U1 spliceosomal snRNA^[3].

[edit] References

^ Darzacq, X; Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21: 2746–2756. doi:10.1093/emboj/21.11.2746. PMID 12032087.
^ Kiss AM, Jády BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
^ Lestrade L, Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34 (Database issue): D158–62. doi:10.1093/nar/gkj002. PMID 16381836.