From Wikipedia, the free encyclopedia
| Small Cajal body specific RNA 14 |
 |
| Type: |
Gene; snRNA; guide; scaRNA; |
| 2° structure: |
Predicted; RNAalifold |
| Seed alignment: |
Marantidis E. |
| Avg length: |
129.0 nucleotides |
| Avg identity: |
69% |
|
Small Cajal body specific RNAs (scaRNAs) are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs.[3] U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 identified in[4] and also included in this family. U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7.[5]
[edit] References
- ^ Darzacq, X; Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21: 2746–2756. doi:10.1093/emboj/21.11.2746. PMID 12032087.
- ^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
- ^ Vitali, P; Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res. 31: 6543–6551. doi:10.1093/nar/gkg849. PMID 14602913.
- ^ Huttenhofer, A; Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20: 2943–2953. doi:10.1093/emboj/20.11.2943. PMID 11387227.
- ^ Schattner, P; Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12: 15–25. doi:10.1261/rna.2210406. PMID 16373490.
[edit] External links
