From Wikipedia, the free encyclopedia
| Small Cajal body specific RNA 11 |
 |
| Type: |
Gene; snRNA; guide; scaRNA; |
| 2° structure: |
Predicted; RNAalifold |
| Seed alignment: |
Marantidis E. |
| Avg length: |
137.3 nucleotides |
| Avg identity: |
79% |
|
scaRNAs are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] ACA57 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1.[1] ACA57 is predicted to guide the pseudouridylation of the U5 spliceosomal RNA at position U43.[3]
[edit] References
- ^ a b Darzacq, X; Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21: 2746–2756. doi:10.1093/emboj/21.11.2746. PMID 12032087.
- ^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
- ^ Kiss, AM; Jady BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol Cell Biol. 24: 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
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