SMARCC2

From Wikipedia, the free encyclopedia

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Identifiers

SMARCC2; Rsc8; BAF170; CRACC2

External IDs

OMIM: 601734 MGI: 1915344 HomoloGene: 2312

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • transcription coactivator activity • protein binding
Cellular Component:	• chromatin • nucleus • nucleoplasm • SWI/SNF complex • transcriptional repressor complex
Biological Process:	• chromatin assembly or disassembly • chromatin remodeling • transcription • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003075 (mRNA)
NP_003066 (protein)

NM_198160 (mRNA)
NP_937803 (protein)

Location

Chr 12: 54.84 - 54.87 Mb

Chr 10: 127.86 - 127.89 Mb

Pubmed search

[1]

[2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2, also known as SMARCC2, is a human gene.^[1]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2.

[edit] Further reading

Wang W, Xue Y, Zhou S, et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes.". Genes Dev. 10 (17): 2117–30. PMID 8804307.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.". EMBO J. 15 (19): 5370–82. PMID 8895581.
Wang W, Chi T, Xue Y, et al. (1998). "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 492–8. PMID 9435219.
Ring HZ, Vameghi-Meyers V, Wang W, et al. (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.". Genomics 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.". Mol. Cell 3 (2): 247–53. PMID 10078207.
Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.". Cell 102 (2): 257–65. PMID 10943845.
Kadam S, McAlpine GS, Phelan ML, et al. (2000). "Functional selectivity of recombinant mammalian SWI/SNF subunits.". Genes Dev. 14 (19): 2441–51. PMID 11018012.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMID 11078522.
Sif S, Saurin AJ, Imbalzano AN, Kingston RE (2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.". Genes Dev. 15 (5): 603–18. doi:10.1101/gad.872801. PMID 11238380.
Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Battaglioli E, Andrés ME, Rose DW, et al. (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex.". J. Biol. Chem. 277 (43): 41038–45. doi:10.1074/jbc.M205691200. PMID 12192000.
Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex.". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMID 12368262.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.". Mol. Cell. Biol. 23 (8): 2942–52. PMID 12665591.
Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.". Cell 113 (7): 905–17. PMID 12837248.
Hsiao PW, Fryer CJ, Trotter KW, et al. (2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.". Mol. Cell. Biol. 23 (17): 6210–20. PMID 12917342.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Kuwabara T, Hsieh J, Nakashima K, et al. (2004). "A small modulatory dsRNA specifies the fate of adult neural stem cells.". Cell 116 (6): 779–93. PMID 15035981.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.