SMARCA5

From Wikipedia, the free encyclopedia

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Identifiers

SMARCA5; ISWI; SNF2H; WCRF135; hISWI; hSNF2H

External IDs

OMIM: 603375 MGI: 1935129 HomoloGene: 55764

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • RNA polymerase II transcription factor activity • helicase activity • ATP binding • hydrolase activity • ATPase activity • histone binding
Cellular Component:	• condensed chromosome • nucleus • nucleoplasm • RSF complex
Biological Process:	• nucleosome assembly • chromatin remodeling • transcription initiation • regulation of transcription from RNA polymerase II promoter • nucleosome positioning

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003601 (mRNA)
NP_003592 (protein)

NM_053124 (mRNA)
NP_444354 (protein)

Location

Chr 4: 144.65 - 144.69 Mb

n/a

Pubmed search

[1]

[2]

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5, also known as SMARCA5, is a human gene.^[1]

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.

[edit] Further reading

Dirscherl SS, Krebs JE (2005). "Functional diversity of ISWI complexes.". Biochem. Cell Biol. 82 (4): 482–9. doi:10.1139/o04-044. PMID 15284901.
Aihara T, Miyoshi Y, Koyama K, et al. (1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.". Cytogenet. Cell Genet. 81 (3-4): 191–3. PMID 9730600.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro.". Science 282 (5395): 1900–4. PMID 9836642.
Bochar DA, Savard J, Wang W, et al. (2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor.". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. PMID 10655480.
Poot RA, Dellaire G, Hülsmann BB, et al. (2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMID 10880450.
Stopka T, Zakova D, Fuchs O, et al. (2000). "Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia.". Leukemia 14 (7): 1247–52. PMID 10914549.
Aalfs JD, Narlikar GJ, Kingston RE (2001). "Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H.". J. Biol. Chem. 276 (36): 34270–8. doi:10.1074/jbc.M104163200. PMID 11435432.
Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMID 11532953.
Bozhenok L, Wade PA, Varga-Weisz P (2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.". EMBO J. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMID 11980720.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.
Hakimi MA, Bochar DA, Schmiesing JA, et al. (2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes.". Nature 418 (6901): 994–8. doi:10.1038/nature01024. PMID 12198550.
Yasui D, Miyano M, Cai S, et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances.". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
Collins N, Poot RA, Kukimoto I, et al. (2003). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin.". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Loyola A, Huang JY, LeRoy G, et al. (2003). "Functional analysis of the subunits of the chromatin assembly factor RSF.". Mol. Cell. Biol. 23 (19): 6759–68. PMID 12972596.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system.". Biochem. Biophys. Res. Commun. 318 (2): 544–55. doi:10.1016/j.bbrc.2004.04.058. PMID 15120635.
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMID 15148359.