SMAP1

From Wikipedia, the free encyclopedia

Stromal membrane-associated protein 1

PDB rendering based on 2crr.

Available structures: 2crr

Identifiers

Symbol(s)

SMAP1; SMAP-1; FLJ13159; FLJ42245

External IDs

MGI: 2138261 HomoloGene: 68754

Gene ontology
Molecular Function:	• GTPase activator activity • zinc ion binding • metal ion binding
Cellular Component:	• membrane
Biological Process:	• regulation of GTPase activity • positive regulation of erythrocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001044305 (mRNA)
NP_001037770 (protein)

XM_977542 (mRNA)
XP_982636 (protein)

Location

Chr 6: 71.43 - 71.63 Mb

Chr 1: 23.8 - 23.88 Mb

Pubmed search

[1]

[2]

Stromal membrane-associated protein 1, also known as SMAP1, is a human gene.^[1]

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMAP1 stromal membrane-associated protein 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Sato Y, Hong HN, Yanai N, Obinata M (1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment.". J. Biochem. 124 (1): 209-16. PMID 9644265.
Marcos I, Borrego S, Rodríguez de Córdoba S, et al. (2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene.". Gene 292 (1-2): 167-71. PMID 12119110.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis.". Mol. Biol. Cell 16 (4): 1617-28. doi:10.1091/mbc.E04-08-0683. PMID 15659652.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa.". Int. J. Mol. Med. 16 (6): 1163-7. PMID 16273301.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.