SLPI

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Secretory leukocyte peptidase inhibitor
Identifiers
Symbol(s) SLPI; ALK1; ALP; MPI; BLPI; HUSI; HUSI-I; WAP4; WFDC4
External IDs OMIM: 107285 MGI: 109297 HomoloGene: 2305
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6590 20568
Ensembl ENSG00000124107 ENSMUSG00000017002
Uniprot P03973 Q548X8
Refseq NM_003064 (mRNA)
NP_003055 (protein)		 NM_011414 (mRNA)
NP_035544 (protein)
Location Chr 20: 43.31 - 43.32 Mb Chr 2: 164.05 - 164.06 Mb
Pubmed search [1] [2]

Secretory leukocyte peptidase inhibitor, also known as SLPI, is a human gene.[1]

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.[1]

[edit] References

  1. ^ a b Entrez Gene: SLPI secretory leukocyte peptidase inhibitor.

[edit] Further reading

  • Fritz H (1989). "Human mucus proteinase inhibitor (human MPI). Human seminal inhibitor I (HUSI-I), antileukoprotease (ALP), secretory leukocyte protease inhibitor (SLPI).". Biol. Chem. Hoppe-Seyler 369 Suppl: 79–82. PMID 3060147. 
  • Sallenave JM (2003). "The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease.". Respir. Res. 1 (2): 87–92. PMID 11667971. 
  • Rogaev EI, Keryanov SA, Malyako YK (1993). "Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci.". Hum. Mol. Genet. 1 (4): 285. PMID 1363870. 
  • Abe T, Kobayashi N, Yoshimura K, et al. (1991). "Expression of the secretory leukoprotease inhibitor gene in epithelial cells.". J. Clin. Invest. 87 (6): 2207–15. PMID 1674946. 
  • Sallenave JM, Ryle AP (1991). "Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.". Biol. Chem. Hoppe-Seyler 372 (1): 13–21. PMID 2039600. 
  • Eisenberg SP, Hale KK, Heimdal P, Thompson RC (1990). "Location of the protease-inhibitory region of secretory leukocyte protease inhibitor.". J. Biol. Chem. 265 (14): 7976–81. PMID 2110563. 
  • Grütter MG, Fendrich G, Huber R, Bode W (1988). "The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.". EMBO J. 7 (2): 345–51. PMID 3366116. 
  • Thompson RC, Ohlsson K (1986). "Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6692–6. PMID 3462719. 
  • Seemüller U, Arnhold M, Fritz H, et al. (1986). "The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor.". FEBS Lett. 199 (1): 43–8. PMID 3485543. 
  • Heinzel R, Appelhans H, Gassen G, et al. (1986). "Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus.". Eur. J. Biochem. 160 (1): 61–7. PMID 3533531. 
  • Stetler G, Brewer MT, Thompson RC (1986). "Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases.". Nucleic Acids Res. 14 (20): 7883–96. PMID 3640338. 
  • Westin U, Fryksmark U, Polling A, Ohlsson K (1994). "Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa.". Acta Otolaryngol. 114 (2): 199–202. PMID 7515550. 
  • Ohlsson K, Bjartell A, Lilja H (1995). "Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization.". J. Androl. 16 (1): 64–74. PMID 7539415. 
  • Belorgey D, Dirrig S, Amouric M, et al. (1996). "Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin.". Biochem. J. 313 ( Pt 2): 555–60. PMID 8573092. 
  • Kikuchi T, Abe T, Hoshi S, et al. (1999). "Structure of the murine secretory leukoprotease inhibitor (Slpi) gene and chromosomal localization of the human and murine SLPI genes.". Am. J. Respir. Cell Mol. Biol. 19 (6): 875–80. PMID 9843921. 
  • Westin U, Polling A, Ljungkrantz I, Ohlsson K (1999). "Identification of SLPI (secretory leukocyte protease inhibitor) in human mast cells using immunohistochemistry and in situ hybridisation.". Biol. Chem. 380 (4): 489–93. PMID 10355635. 
  • Mulligan MS, Lentsch AB, Huber-Lang M, et al. (2000). "Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor.". Am. J. Pathol. 156 (3): 1033–9. PMID 10702419. 
  • Nyström M, Bergenfeldt M, Ljungcrantz I, et al. (2000). "Production of secretory leucocyte protease inhibitor (SLPI) in human pancreatic beta-cells.". Mediators Inflamm. 8 (3): 147–51. PMID 10704052. 
  • Si-Tahar M, Merlin D, Sitaraman S, Madara JL (2000). "Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells.". Gastroenterology 118 (6): 1061–71. PMID 10833481. 
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