SLK (gene)

From Wikipedia, the free encyclopedia

STE20-like kinase (yeast)

PDB rendering based on 2j51.

Available structures: 2j51, 2jfl, 2jfm, 2uv2

Identifiers

Symbol(s)

SLK; KIAA0204; STK2; MGC133067; bA16H23.1; se20-9

External IDs

MGI: 103241 HomoloGene: 22515

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • nuclease activity • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• nucleotide-excision repair • protein amino acid phosphorylation • apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014720 (mRNA)
NP_055535 (protein)

NM_009289 (mRNA)
NP_033315 (protein)

Location

Chr 10: 105.72 - 105.78 Mb

Chr 19: 47.63 - 47.7 Mb

Pubmed search

[1]

[2]

STE20-like kinase (yeast), also known as SLK, is a human gene.^[1]

[edit] References

^ Entrez Gene: SLK STE20-like kinase (yeast).

[edit] Further reading

Yan Y, Nguyen H, Dalmasso G, et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.". Biochim. Biophys. Acta 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMID 17321610.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chaar Z, O'reilly P, Gelman I, Sabourin LA (2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.". J. Biol. Chem. 281 (38): 28193–9. doi:10.1074/jbc.M605665200. PMID 16837460.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Dan I, Watanabe NM, Kusumi A (2001). "The Ste20 group kinases as regulators of MAP kinase cascades.". Trends Cell Biol. 11 (5): 220–30. PMID 11316611.
Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMID 11149944.
Yamada E, Tsujikawa K, Itoh S, et al. (2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK.". Biochim. Biophys. Acta 1495 (3): 250–62. PMID 10699464.
Sabourin LA, Tamai K, Seale P, et al. (2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region.". Mol. Cell. Biol. 20 (2): 684–96. PMID 10611247.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Celenza JL, Carlson M (1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase.". Science 233 (4769): 1175–80. PMID 3526554.