SLITRK5

From Wikipedia, the free encyclopedia


SLIT and NTRK-like family, member 5
Identifiers
Symbol(s) SLITRK5; KIAA0918; LRRC11; bA364G4.2
External IDs OMIM: 609680 MGI: 2679448 HomoloGene: 9193
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26050 75409
Ensembl ENSG00000165300 ENSMUSG00000033214
Uniprot O94991 Q69ZV6
Refseq NM_015567 (mRNA)
NP_056382 (protein)		 NM_029273 (mRNA)
NP_083549 (protein)
Location Chr 13: 87.12 - 87.13 Mb Chr 14: 110.56 - 110.56 Mb
Pubmed search [1] [2]

SLIT and NTRK-like family, member 5, also known as SLITRK5, is a human gene.[1]

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5.

[edit] Further reading

  • Amanchy R, Kalume DE, Iwahori A, et al. (2006). "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).". J. Proteome Res. 4 (5): 1661-71. doi:10.1021/pr050134h. PMID 16212419. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Aruga J, Yokota N, Mikoshiba K (2004). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.". Gene 315: 87-94. PMID 14557068. 
  • Aruga J, Mikoshiba K (2004). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.". Mol. Cell. Neurosci. 24 (1): 117-29. PMID 14550773. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485. 
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