SLITRK1 (gene)
From Wikipedia, the free encyclopedia
SLIT and NTRK-like family, member 1
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Identifiers | ||||||||||||||
Symbol(s) | SLITRK1; KIAA0918; KIAA1910; LRRC12; RP11-395N17.1 | |||||||||||||
External IDs | OMIM: 609678 MGI: 2679446 HomoloGene: 14174 | |||||||||||||
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Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 114798 | 76965 | ||||||||||||
Ensembl | ENSG00000178235 | ENSMUSG00000075478 | ||||||||||||
Uniprot | Q96PX8 | Q69Z70 | ||||||||||||
Refseq | NM_052910 (mRNA) NP_443142 (protein) |
NM_199065 (mRNA) NP_951020 (protein) |
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Location | Chr 13: 83.35 - 83.35 Mb | Chr 14: 107.79 - 107.8 Mb | ||||||||||||
Pubmed search | [1] | [2] |
SLIT and NTRK-like family, member 1, also known as SLITRK1, is a human gene.[1]
Members of the SLITRK family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][1]
[edit] References
[edit] Further reading
- Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179-87. PMID 11572484.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi: . PMID 12975309.
- Aruga J, Mikoshiba K (2004). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.". Mol. Cell. Neurosci. 24 (1): 117-29. PMID 14550773.
- Aruga J, Yokota N, Mikoshiba K (2004). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.". Gene 315: 87-94. PMID 14557068.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi: . PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.
- Abelson JF, Kwan KY, O'Roak BJ, et al. (2005). "Sequence variants in SLITRK1 are associated with Tourette's syndrome.". Science 310 (5746): 317-20. doi: . PMID 16224024.
- Burton A (2006). "SLITRK1 trouble in Tourette's syndrome.". Lancet neurology 4 (12): 801. PMID 16323357.
- Wendland JR, Kruse MR, Murphy DL (2006). "Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder.". Mol. Psychiatry 11 (9): 802-4. doi: . PMID 16936762.
- Zuchner S, Cuccaro ML, Tran-Viet KN, et al. (2006). "SLITRK1 mutations in trichotillomania.". Mol. Psychiatry 11 (10): 887-9. doi: . PMID 17003809.