SLCO1A2

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Solute carrier organic anion transporter family, member 1A2
Identifiers
Symbol(s) SLCO1A2; OATP; OATP-A; OATP1A2; SLC21A3
External IDs OMIM: 602883 MGI: 1351896 HomoloGene: 56603
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6579 28250
Ensembl ENSG00000084453 ENSMUSG00000030237
Uniprot P46721 Q8C7H7
Refseq NM_005075 (mRNA)
NP_005066 (protein)		 NM_030687 (mRNA)
NP_109612 (protein)
Location Chr 12: 21.31 - 21.44 Mb Chr 6: 141.77 - 141.81 Mb
Pubmed search [1] [2]

Solute carrier organic anion transporter family, member 1A2, also known as SLCO1A2, is a human gene.[1]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2.

[edit] Further reading

  • Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver.". Hepatology 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014. 
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.". Gastroenterology 109 (4): 1274–82. PMID 7557095. 
  • Kullak-Ublick GA, Beuers U, Meier PJ, et al. (1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization.". J. Hepatol. 25 (6): 985–7. PMID 9007731. 
  • Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene.". Hepatology 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325. 
  • Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.". FEBS Lett. 424 (3): 173–6. PMID 9539145. 
  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507. 
  • Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595. 
  • Speek M (2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMID 11238933. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119. 
  • Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.". Mol. Pharm. 1 (1): 49–56. PMID 15832500. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other