SLC7A1

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Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Identifiers
Symbol(s) SLC7A1; ATRC1; CAT-1; ERR; HCAT1; REC1L
External IDs OMIM: 104615 MGI: 88117 HomoloGene: 20658
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6541 11987
Ensembl ENSG00000139514 ENSMUSG00000041313
Uniprot P30825 Q3TQZ8
Refseq NM_003045 (mRNA)
NP_003036 (protein)		 NM_007513 (mRNA)
NP_031539 (protein)
Location Chr 13: 28.98 - 29.07 Mb Chr 5: 148.64 - 148.71 Mb
Pubmed search [1] [2]

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1, also known as SLC7A1, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1.

[edit] Further reading

  • Albritton LM, Bowcock AM, Eddy RL, et al. (1992). "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14.". Genomics 12 (3): 430-4. PMID 1348489. 
  • Yoshimoto T, Yoshimoto E, Meruelo D (1991). "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.". Virology 185 (1): 10-7. PMID 1718082. 
  • Kamath SG, Furesz TC, Way BA, Smith CH (1999). "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.". J. Membr. Biol. 171 (1): 55-62. PMID 10485994. 
  • Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.". Amino Acids 21 (2): 211-9. PMID 11665818. 
  • Cariappa R, Heath-Monnig E, Furesz TC, et al. (2002). "Stable polarized expression of hCAT-1 in an epithelial cell line.". J. Membr. Biol. 186 (1): 23-30. doi:10.1007/s00232-001-0133-y. PMID 11891586. 
  • Furesz TC, Heath-Monnig E, Kamath SG, Smith CH (2003). "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.". J. Membr. Biol. 189 (1): 27-33. doi:10.1007/s00232-002-1001-0. PMID 12202949. 
  • Kizhatil K, Albritton LM (2002). "System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells.". Am. J. Physiol., Cell Physiol. 283 (6): C1784-94. doi:10.1152/ajpcell.00061.2002. PMID 12388095. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin.". J. Invest. Dermatol. 120 (6): 1016-22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.". Pflugers Arch. 448 (4): 383-94. doi:10.1007/s00424-004-1261-x. PMID 15064952. 
  • Schwartz IF, Iaina A, Benedict Y, et al. (2004). "Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats.". Kidney Int. 65 (4): 1311-9. doi:10.1111/j.1523-1755.2004.00508.x. PMID 15086470. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rotmann A, Strand D, Martiné U, Closs EI (2005). "Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity.". J. Biol. Chem. 279 (52): 54185-92. doi:10.1074/jbc.M409556200. PMID 15491978. 
  • Cui Z, Tuladhar R, Hart SL, et al. (2005). "Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells.". Nitric Oxide 12 (1): 21-30. doi:10.1016/j.niox.2004.11.001. PMID 15631944. 
  • Yang Z, Venardos K, Jones E, et al. (2007). "Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.". Circulation 115 (10): 1269-74. doi:10.1161/CIRCULATIONAHA.106.665836. PMID 17325243. 
  • Kaneko S, Okuda-Ashitaka E, Ando A, et al. (2007). "Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.". Am. J. Physiol., Cell Physiol. 293 (2): C729-37. doi:10.1152/ajpcell.00018.2007. PMID 17494634. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other