SLC7A11

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Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Identifiers
Symbol(s) SLC7A11; CCBR1; xCT
External IDs OMIM: 607933 MGI: 1347355 HomoloGene: 22684
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23657 26570
Ensembl ENSG00000151012 ENSMUSG00000027737
Uniprot Q9UPY5 Q3TN05
Refseq NM_014331 (mRNA)
NP_055146 (protein)		 NM_011990 (mRNA)
NP_036120 (protein)
Location Chr 4: 139.3 - 139.38 Mb Chr 3: 50.46 - 50.54 Mb
Pubmed search [1] [2]

Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, also known as SLC7A11, is a human gene.[1]

SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM][1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11.

[edit] Further reading

  • Sato H, Tamba M, Ishii T, Bannai S (1999). "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins.". J. Biol. Chem. 274 (17): 11455–8. PMID 10206947. 
  • Bridges CC, Kekuda R, Wang H, et al. (2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.". Invest. Ophthalmol. Vis. Sci. 42 (1): 47–54. PMID 11133847. 
  • Sato H, Tamba M, Kuriyama-Matsumura K, et al. (2001). "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.". Antioxid. Redox Signal. 2 (4): 665–71. PMID 11213471. 
  • Shih AY, Murphy TH (2001). "xCt cystine transporter expression in HEK293 cells: pharmacology and localization.". Biochem. Biophys. Res. Commun. 282 (5): 1132–7. doi:10.1006/bbrc.2001.4703. PMID 11302733. 
  • Kim JY, Kanai Y, Chairoungdua A, et al. (2001). "Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.". Biochim. Biophys. Acta 1512 (2): 335–44. PMID 11406111. 
  • Bassi MT, Gasol E, Manzoni M, et al. (2001). "Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.". Pflugers Arch. 442 (2): 286–96. PMID 11417227. 
  • Sasaki H, Sato H, Kuriyama-Matsumura K, et al. (2003). "Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.". J. Biol. Chem. 277 (47): 44765–71. doi:10.1074/jbc.M208704200. PMID 12235164. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.". Biochem. Biophys. Res. Commun. 305 (3): 611–8. PMID 12763038. 
  • Jiménez-Vidal M, Gasol E, Zorzano A, et al. (2004). "Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway.". J. Biol. Chem. 279 (12): 11214–21. doi:10.1074/jbc.M309866200. PMID 14722095. 
  • Gasol E, Jiménez-Vidal M, Chillarón J, et al. (2004). "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.". J. Biol. Chem. 279 (30): 31228–36. doi:10.1074/jbc.M402428200. PMID 15151999. 
  • Bridges CC, Hu H, Miyauchi S, et al. (2004). "Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium.". Invest. Ophthalmol. Vis. Sci. 45 (9): 2906–14. doi:10.1167/iovs.03-1355. PMID 15326101. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kaleeba JA, Berger EA (2006). "Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.". Science 311 (5769): 1921–4. doi:10.1126/science.1120878. PMID 16574866. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other