SLC6A6

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Solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Identifiers
Symbol(s) SLC6A6; MGC10619; MGC131729; TAUT
External IDs OMIM: 186854 MGI: 98488 HomoloGene: 2291
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6533 21366
Ensembl ENSG00000131389 ENSMUSG00000030096
Uniprot P31641 Q3UPI8
Refseq NM_003043 (mRNA)
NP_003034 (protein)		 NM_009320 (mRNA)
NP_033346 (protein)
Location Chr 3: 14.42 - 14.51 Mb Chr 6: 91.65 - 91.72 Mb
Pubmed search [1] [2]

Solute carrier family 6 (neurotransmitter transporter, taurine), member 6, also known as SLC6A6, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6.

[edit] Further reading

  • Uchida S, Kwon HM, Yamauchi A, et al. (1992). "Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8230–4. PMID 1518851. 
  • Ramamoorthy S, Leibach FH, Mahesh VB, et al. (1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.". Biochem. J. 300 ( Pt 3): 893–900. PMID 8010975. 
  • Jhiang SM, Fithian L, Smanik P, et al. (1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.". FEBS Lett. 318 (2): 139–44. PMID 8382624. 
  • Miyamoto Y, Liou GI, Sprinkle TJ (1996). "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.". Curr. Eye Res. 15 (3): 345–9. PMID 8654117. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Mochizuki T, Satsu H, Shimizu M (2002). "Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells.". FEBS Lett. 517 (1-3): 92–6. PMID 12062416. 
  • Han X, Patters AB, Chesney RW (2002). "Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells.". J. Biol. Chem. 277 (42): 39266–73. doi:10.1074/jbc.M205939200. PMID 12163498. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Han X, Chesney RW (2003). "Regulation of taurine transporter gene (TauT) by WT1.". FEBS Lett. 540 (1-3): 71–6. PMID 12681485. 
  • Roos S, Powell TL, Jansson T (2004). "Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation.". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R886–93. doi:10.1152/ajpregu.00232.2004. PMID 15166008. 
  • Satsu H, Manabe M, Shimizu M (2004). "Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.". FEBS Lett. 569 (1-3): 123–8. doi:10.1016/j.febslet.2004.05.062. PMID 15225620. 
  • Mochizuki T, Satsu H, Nakano T, Shimizu M (2005). "Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells.". Biofactors 21 (1-4): 141–4. PMID 15630186. 
  • Mochizuki T, Satsu H, Shimizu M (2005). "Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells.". FEBS Lett. 579 (14): 3069–74. doi:10.1016/j.febslet.2005.04.063. PMID 15907840. 
  • Nakashima E, Pop-Busui R, Towns R, et al. (2006). "Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase.". Antioxid. Redox Signal. 7 (11-12): 1530–42. doi:10.1089/ars.2005.7.1530. PMID 16356117. 
  • Iruloh CG, D'Souza SW, Speake PF, et al. (2007). "Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity.". Am. J. Physiol., Cell Physiol. 292 (1): C332–41. doi:10.1152/ajpcell.00634.2005. PMID 16956961. 
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