SLC4A5

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Solute carrier family 4, sodium bicarbonate cotransporter, member 5
Identifiers
Symbol(s) SLC4A5; MGC129662; NBC4
External IDs OMIM: 606757 MGI: 2443220 HomoloGene: 71686
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57835 232156
Ensembl ENSG00000188687 n/a
Refseq NM_033323 (mRNA)
NP_201580 (protein)		 XM_888058 (mRNA)
XP_893151 (protein)
Location Chr 2: 74.3 - 74.42 Mb n/a
Pubmed search [1] [2]

Solute carrier family 4, sodium bicarbonate cotransporter, member 5, also known as SLC4A5, is a human gene.[1]

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate cotransporter, member 5.

[edit] Further reading

  • Soleimani M, Burnham CE (2002). "Na+:HCO(3-) cotransporters (NBC): cloning and characterization.". J. Membr. Biol. 183 (2): 71-84. PMID 11562789. 
  • Hunt SC, Xin Y, Wu LL, et al. (2006). "Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures.". Hypertension 47 (3): 532-6. doi:10.1161/01.HYP.0000196949.26088.3c. PMID 16365189. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Xu J, Wang Z, Barone S, et al. (2003). "Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant.". Am. J. Physiol. Renal Physiol. 284 (1): F41-50. doi:10.1152/ajprenal.00055.2002. PMID 12388414. 
  • Pushkin A, Abuladze N, Newman D, et al. (2002). "Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued).". Cytogenet. Cell Genet. 95 (3-4): 163-8. PMID 12063394. 
  • Sassani P, Pushkin A, Gross E, et al. (2002). "Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.". Am. J. Physiol., Cell Physiol. 282 (2): C408-16. doi:10.1152/ajpcell.00409.2001. PMID 11788353. 
  • Pushkin A, Abuladze N, Newman D, et al. (2001). "Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization.". IUBMB Life 50 (1): 13-9. PMID 11087115. 
  • Pushkin A, Abuladze N, Newman D, et al. (2000). "Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.". Biochim. Biophys. Acta 1493 (1-2): 215-8. PMID 10978526. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other