SLC47A2

From Wikipedia, the free encyclopedia

Solute carrier family 47, member 2

Identifiers

SLC47A2; MATE2; FLJ31196

External IDs

Gene ontology
Molecular Function:	• drug transporter activity • antiporter activity
Cellular Component:	• membrane
Biological Process:	• multidrug transport

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_152908 (mRNA)
NP_690872 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 17: 19.52 - 19.56 Mb

n/a

Pubmed search

[1]

n/a

Solute carrier family 47, member 2, also known as SLC47A2, is a human gene.^[1]

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MATE2 H+/organic cation antiporter.

[edit] Further reading

Tanihara Y, Masuda S, Sato T, et al. (2007). "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.". Biochem. Pharmacol. 74 (2): 359-71. doi:10.1016/j.bcp.2007.04.010. PMID 17509534.
Omote H, Hiasa M, Matsumoto T, et al. (2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.". Trends Pharmacol. Sci. 27 (11): 587-93. doi:10.1016/j.tips.2006.09.001. PMID 16996621.
Masuda S, Terada T, Yonezawa A, et al. (2006). "Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.". J. Am. Soc. Nephrol. 17 (8): 2127-35. doi:10.1681/ASN.2006030205. PMID 16807400.
Otsuka M, Matsumoto T, Morimoto R, et al. (2006). "A human transporter protein that mediates the final excretion step for toxic organic cations.". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923-8. doi:10.1073/pnas.0506483102. PMID 16330770.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304-51. doi:10.1126/science.1058040. PMID 11181995.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.