SLC38A1

From Wikipedia, the free encyclopedia

Solute carrier family 38, member 1

Identifiers

SLC38A1; NAT2; SAT1; ATA1; SNAT1

External IDs

OMIM: 608490 MGI: 2145895 HomoloGene: 12745

Gene ontology
Molecular Function:	• sodium:amino acid symporter activity • neutral amino acid transmembrane transporter activity
Cellular Component:	• integral to membrane
Biological Process:	• neutral amino acid transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001077484 (mRNA)
NP_001070952 (protein)

NM_134086 (mRNA)
NP_598847 (protein)

Location

Chr 12: 44.87 - 44.95 Mb

Chr 15: 96.4 - 96.47 Mb

Pubmed search

[1]

[2]

Solute carrier family 38, member 1, also known as SLC38A1, is a human gene.^[1]

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SLC38A1 solute carrier family 38, member 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Wang H, Huang W, Sugawara M, et al. (2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.". Biochem. Biophys. Res. Commun. 273 (3): 1175–9. doi:10.1006/bbrc.2000.3061. PMID 10891391.
Gu S, Roderick HL, Camacho P, Jiang JX (2001). "Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.". J. Biol. Chem. 276 (26): 24137–44. doi:10.1074/jbc.M009003200. PMID 11325958.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Melone M, Quagliano F, Barbaresi P, et al. (2004). "Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex.". Cereb. Cortex 14 (5): 562–74. doi:10.1093/cercor/bhh018. PMID 15054072.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Kondoh N, Imazeki N, Arai M, et al. (2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.". Int. J. Oncol. 31 (1): 81–7. PMID 17549407.