SLC36A1

From Wikipedia, the free encyclopedia

Solute carrier family 36 (proton/amino acid symporter), member 1

Identifiers

SLC36A1; PAT1; LYAAT1; TRAMD3

External IDs

OMIM: 606561 MGI: 2445299 HomoloGene: 70571

Gene ontology
Molecular Function:	• hydrogen:amino acid symporter activity • amino acid transmembrane transporter activity • L-alanine transmembrane transporter activity • glycine transmembrane transporter activity • L-proline transmembrane transporter activity • symporter activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• transport • amino acid transport • L-alanine transport • glycine transport • proline transport • proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_078483 (mRNA)
NP_510968 (protein)

NM_153139 (mRNA)
NP_694779 (protein)

Location

Chr 5: 150.81 - 150.85 Mb

Chr 11: 55.05 - 55.08 Mb

Pubmed search

[1]

[2]

Solute carrier family 36 (proton/amino acid symporter), member 1, also known as SLC36A1, is a human gene.^[1]

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1.

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Sagné C, Agulhon C, Ravassard P, et al. (2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7206–11. doi:10.1073/pnas.121183498. PMID 11390972.
Boll M, Foltz M, Rubio-Aliaga I, et al. (2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters.". J. Biol. Chem. 277 (25): 22966–73. doi:10.1074/jbc.M200374200. PMID 11959859.
Chen Z, Fei YJ, Anderson CM, et al. (2003). "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.". J. Physiol. (Lond.) 546 (Pt 2): 349–61. PMID 12527723.
Wreden CC, Johnson J, Tran C, et al. (2003). "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.". J. Neurosci. 23 (4): 1265–75. PMID 12598615.
Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes.". Genomics 82 (1): 47–56. PMID 12809675.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes.". Mamm. Genome 15 (2): 114–25. PMID 15058382.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Anderson CM, Grenade DS, Boll M, et al. (2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.". Gastroenterology 127 (5): 1410–22. PMID 15521011.
Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1).". J. Cell. Physiol. 204 (2): 604–13. doi:10.1002/jcp.20337. PMID 15754324.
Abbot EL, Grenade DS, Kennedy DJ, et al. (2006). "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1.". Br. J. Pharmacol. 147 (3): 298–306. doi:10.1038/sj.bjp.0706557. PMID 16331283.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Kuan YH, Gruebl T, Soba P, et al. (2007). "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.". J. Biol. Chem. 281 (52): 40114–23. doi:10.1074/jbc.M605407200. PMID 17050537.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)