SLC34A3

From Wikipedia, the free encyclopedia

Solute carrier family 34 (sodium phosphate), member 3

Identifiers

SLC34A3; FLJ38680; HHRH; NPTIIc

External IDs

OMIM: 609826 MGI: 2159410 HomoloGene: 15444

Gene ontology
Molecular Function:	• sodium:phosphate symporter activity • symporter activity • sodium-dependent phosphate transmembrane transporter activity • sodium ion binding
Cellular Component:	• brush border • membrane • integral to membrane • apical plasma membrane
Biological Process:	• ion transport • sodium ion transport • phosphate transport • cellular phosphate ion homeostasis

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001133456 (mRNA)
XP_001133456 (protein)

NM_080854 (mRNA)
NP_543130 (protein)

Location

n/a

Chr 2: 25.05 - 25.06 Mb

Pubmed search

[1]

[2]

Solute carrier family 34 (sodium phosphate), member 3, also known as SLC34A3, is a human gene.^[1]

SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney (Segawa et al., 2002).[supplied by OMIM]^[1]

[edit] See also

MeSH SLC34A3+protein,+human

[edit] References

^ ^a ^b Entrez Gene: SLC34A3 solute carrier family 34 (sodium phosphate), member 3.

[edit] Further reading

Forster IC, Hernando N, Biber J, Murer H (2006). "Proximal tubular handling of phosphate: A molecular perspective.". Kidney Int. 70 (9): 1548-59. doi:10.1038/sj.ki.5001813. PMID 16955105.
Yamamoto T, Michigami T, Aranami F, et al. (2007). "Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function.". J. Bone Miner. Metab. 25 (6): 407-13. doi:10.1007/s00774-007-0776-6. PMID 17968493.
Lorenz-Depiereux B, Benet-Pages A, Eckstein G, et al. (2007). "Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.". Am. J. Hum. Genet. 78 (2): 193-201. doi:10.1086/499410. PMID 16358215.
Bergwitz C, Roslin NM, Tieder M, et al. (2007). "SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis.". Am. J. Hum. Genet. 78 (2): 179-92. doi:10.1086/499409. PMID 16358214.
Ehnes C, Forster IC, Bacconi A, et al. (2005). "Structure-function relations of the first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter: II. Substrate interaction and voltage dependency of two functionally important sites.". J. Gen. Physiol. 124 (5): 489-503. doi:10.1085/jgp.200409061. PMID 15504899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733-45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Segawa H, Kaneko I, Takahashi A, et al. (2002). "Growth-related renal type II Na/Pi cotransporter.". J. Biol. Chem. 277 (22): 19665-72. doi:10.1074/jbc.M200943200. PMID 11880379.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)