SLC23A1

From Wikipedia, the free encyclopedia

Solute carrier family 23 (nucleobase transporters), member 1

Identifiers

SLC23A1; SLC23A2; MGC22361; SVCT1; YSPL3

External IDs

OMIM: 603790 MGI: 1341903 HomoloGene: 40769

Gene ontology
Molecular Function:	• transporter activity • nucleobase transmembrane transporter activity • symporter activity • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • ion transport • sodium ion transport • nucleobase transport

Orthologs

Human

Mouse

Refseq

NM_005847 (mRNA)
NP_005838 (protein)

NM_011397 (mRNA)
NP_035527 (protein)

Location

Chr 5: 138.73 - 138.75 Mb

Chr 18: 35.74 - 35.75 Mb

Pubmed search

[1]

[2]

Solute carrier family 23 (nucleobase transporters), member 1, also known as SLC23A1, is a human gene.^[1]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1.

[edit] Further reading

Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells.". Mol. Membr. Biol. 18 (1): 87–95. PMID 11396616.
Faaland CA, Race JE, Ricken G, et al. (1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.". Biochim. Biophys. Acta 1442 (2-3): 353–60. PMID 9804989.
Tsukaguchi H, Tokui T, Mackenzie B, et al. (1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters.". Nature 399 (6731): 70–5. doi:10.1038/19986. PMID 10331392.
Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.". Genomics 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
Wang H, Dutta B, Huang W, et al. (1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant.". Biochim. Biophys. Acta 1461 (1): 1–9. PMID 10556483.
Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.". FEBS Lett. 460 (3): 480–4. PMID 10556521.
Wang Y, Mackenzie B, Tsukaguchi H, et al. (2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1.". Biochem. Biophys. Res. Commun. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.
Erichsen HC, Eck P, Levine M, Chanock S (2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).". J. Nutr. 131 (10): 2623–7. PMID 11584081.
Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.
Maulén NP, Henríquez EA, Kempe S, et al. (2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.". J. Biol. Chem. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.
Liang WJ, Johnson D, Ma LS, et al. (2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected].". Am. J. Physiol., Cell Physiol. 283 (6): C1696–704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Subramanian VS, Marchant JS, Boulware MJ, Said HM (2004). "A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia.". J. Biol. Chem. 279 (26): 27719–28. doi:10.1074/jbc.M400876200. PMID 15084584.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.". Biochem. Biophys. Res. Commun. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
Erichsen HC, Engel SA, Eck PK, et al. (2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.". Am. J. Epidemiol. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.
Kang JS, Kim HN, Jung da J, et al. (2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane.". J. Invest. Dermatol. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)